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QUICK ANSWER
"Hace cuánto tiempo" is a form of "hace cuánto tiempo", a phrase which is often translated as "how long". "Desde cuándo" is a phrase which is often translated as "since when". Learn more about the difference between "desde cuándo" and "hace cuánto tiempo" below.
desde cuándo()
A phrase is a group of words commonly used together (e.g., once upon a time).
1. (general)
hace cuánto tiempo()
A phrase is a group of words commonly used together (e.g., once upon a time).
a. how long
Si supieras hace cuánto tiempo te estoy esperando, también estarías enojada.If you knew how long I've been waiting for you, you'd also be angry.